Una relazione sull'uso delle statine nei pazienti psoriasici
La psoriasi rappresenta una malattia comune della pelle che si manifesta clinicamente con lesioni cutanee croniche. È stato osservato che la psoriasi si associa ad un aumento del rischio di malattie cardiovascolari, a cui contribuisce l'inappropriato metabolismo lipidico.
Clinicamente, l'efficacia di questo nuovo trattamento è stata confermata dalla significativa riduzione del punteggio PASI, anche se ad oggi sono stati segnalati alcuni casi in cui l'atorvastatina o la pravastatina hanno peggiorato la psoriasi. Sulla base di questi risultati, sembra che le statine rappresentino una promettente classe di farmaci e pertanto potrebbero essere usate ampiamente nella psoriasi.
Storia della pubblicazione:
Titolo: Rational for statin use in psoriatic patients
Rivista: Archives of Dermatological Research
Autori: Jerzy Mosiewicz, Aldona Pietrzak, Grażyna Chodorowska, Marcin Trojnar, Jacek Szepietowski, Kristian Reich, Manfredi Rizzo
Affiliazioni:
Abstract:
Psoriasis represents a common skin disease which is clinically manifested by chronic cutaneous lesions. It has been observed that psoriasis is associated with an increased risk of cardiovascular diseases, which is contributed to the inappropriate lipid metabolism. Statins are commonly used in clinical practice to lower cholesterol concentration and, accordingly, decrease the individual risk of developing a cardiovascular episode. There have been reports that statin administration could also result in better management of psoriasis. The observed beneficial effects are contributed to the effects on lipid metabolism, including that in skin, as well as anti-inflammatory and immunomodulatory properties of statins. Simvastatin and atorvastatin were found to improve the clinical outcome in patients with psoriatic skin lesions. Clinically, the effectiveness of this novel treatment was confirmed by the significant reduction in PASI score. To date several cases have been reported in which atorvastatin or pravastatin worsened psoriasis. Based on these results, it seems that statins represent a promising class of medications which could be extensively used in psoriasis.
